Ketamine Therapy for PTSD

Trauma changes the brain. Ketamine can help change it back. A new approach to healing for those living with post-traumatic stress disorder.

13M
Americans with PTSD
67%
Response Rate
50%
Don't Respond to SSRIs
Rapid
Symptom Reduction

Why Ketamine for PTSD?

PTSD affects approximately 6% of the U.S. population at some point in their lives. Current FDA-approved treatments—sertraline and paroxetine—help only about half of patients, and therapy approaches like prolonged exposure can be difficult to tolerate. Ketamine offers a neurobiological approach to trauma recovery.

  • Rapidly reduces PTSD symptoms including flashbacks, nightmares, and hyperarousal
  • Promotes neuroplasticity to help the brain process and recontextualize trauma
  • Can make trauma-focused therapy more effective
  • Works when SSRIs and other first-line PTSD treatments haven't helped
  • Creates a window of emotional flexibility for therapeutic breakthrough

How Ketamine Helps Process Trauma

PTSD involves fear memories that have become "stuck"—encoded too strongly in the amygdala and resistant to extinction. Ketamine promotes memory reconsolidation and neuroplasticity, creating an opportunity for the brain to reprocess traumatic memories in a less threatening context.

  • Facilitates fear extinction by modulating glutamate signaling
  • Reduces amygdala hyperactivity (the brain's fear center)
  • Enhances prefrontal cortex regulation of emotional responses
  • Supports memory reconsolidation—updating how trauma memories are stored
  • Creates a temporary state of cognitive flexibility for therapeutic work

Who Is a Good Candidate?

Ketamine therapy for PTSD is appropriate for adults who have experienced trauma and haven't found adequate relief from existing treatments.

  • Adults 18+ diagnosed with PTSD or complex PTSD
  • Tried at least one PTSD treatment (medication or therapy) without adequate relief
  • Experiencing significant symptoms: flashbacks, nightmares, hypervigilance, avoidance
  • Stable enough for at-home treatment with a companion present
  • No active psychosis or severe dissociative disorders
  • Ideally engaged in concurrent trauma-focused therapy

Safe, Supported Treatment at Home

For many people with PTSD, clinical environments can be triggering. Our at-home model provides treatment in the environment where you feel safest.

  • Treatment in your own safe space—no clinical triggers
  • Trusted companion required for every session
  • AI-guided sessions with grounding exercises if distress arises
  • Emergency support available with one tap in the app
  • Integration tools specifically designed for trauma processing
  • Physician follow-ups to monitor progress and adjust treatment

Clinical Evidence for Ketamine & PTSD

A single ketamine infusion significantly reduced PTSD symptom severity within 24 hours compared to midazolam, with 67% of patients showing clinically meaningful improvement. (Feder et al., 2014 (JAMA Psychiatry))

Repeated ketamine infusions combined with psychotherapy produced significant and sustained PTSD symptom reduction, with benefits maintained at 30-day follow-up. (Feder et al., 2021 (American Journal of Psychiatry))

Repeated IV ketamine infusions produced significant reductions in PTSD symptoms in combat veterans who had not responded to other treatments. (Albott et al., 2018 (Journal of Clinical Psychiatry))

Frequently Asked Questions

Can ketamine help with combat-related PTSD?

Yes. Clinical studies, including trials with combat veterans, have shown significant PTSD symptom reduction with ketamine. Veterans who hadn't responded to other treatments experienced meaningful improvement in flashbacks, nightmares, and hypervigilance.

Will ketamine make me relive my trauma?

Ketamine is not a psychedelic that forces you to confront memories. While some patients may have emotional or visual experiences, the treatment creates a state of neuroplasticity that helps the brain process trauma more gently. Our AI companion provides grounding support throughout, and your companion is always nearby.

Should I continue therapy while doing ketamine treatment?

We strongly recommend it. Ketamine creates a window of enhanced neuroplasticity that can make trauma-focused therapy (EMDR, CPT, prolonged exposure) significantly more effective. The combination of ketamine + therapy often produces better outcomes than either alone.

How is dissociation during treatment different from PTSD dissociation?

PTSD-related dissociation is an involuntary defense mechanism. Ketamine-induced dissociation is controlled, time-limited (30-60 minutes), and occurs in a safe, supported environment. Many patients describe it as a peaceful sense of distance that actually helps them process difficult emotions.

How many sessions are needed for PTSD?

Most treatment protocols for PTSD involve 6-12 sessions over 1-3 months. Some patients notice improvement after the first few sessions, while others benefit from a longer course. Your physician will tailor the protocol based on your specific symptoms and response.

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