Compare at-home ketamine providers
Four at-home ketamine companies dominate the telehealth market. They differ on three things that matter most: clinical model (session-based vs. daily microdose), who oversees you (one physician, a network, or a coach), and price. This page is the honest side-by-side — written by the physician who runs one of them.
For modality comparisons (IV clinics, Spravato) and medication-class comparisons (ketamine vs. SSRIs), see the separate guides below.
At-home ketamine providers compared
* Discreet Ketamine's $250/mo is the clinical fee. Pharmacy medication ($75–$150/mo) and shipping are billed separately by the compounding pharmacy. Full pricing breakdown.
| Provider | Clinical model | Pricing | Dose range | Oversight | States |
|---|---|---|---|---|---|
Discreet Ketamine That's us | Session-based therapeutic dose | $250 / mo all-in* | 100-400 mg sublingual | Same physician | FL, NJ |
Mindbloom | Session-based therapeutic dose | ~$1,158 / 6 sessions ($193+/session) | 200-400 mg sublingual | Network clinicians | 38+ states |
Joyous | Daily microdose | $129 / mo | 15-75 mg daily | Network clinicians | 30+ states |
Nue Life | Session-based + coaching | ~$1,160 / program | 200-500 mg sublingual | Coach + clinician | 30+ states |
Head-to-head deep dives
Discreet vs. Mindbloom
The largest at-home network vs. single-physician continuity. Side-by-side pricing, dosing, and who actually sees your chart.
Discreet vs. Joyous
Therapeutic-dose session-based therapy vs. daily microdose model. What the clinical evidence actually supports for each.
Discreet vs. Nue Life
Physician-led vs. coach-led integration. How the post-dosing support model differs and what that means for outcomes.
Beyond at-home providers
At-home isn't the only ketamine modality, and ketamine isn't the only medication for depression. Two further comparisons round out the picture.
At-home ketamine vs. IV infusion clinics
Cost ($400–$800/session vs. $250/mo all-in), evidence base, access, and which patient profile actually benefits from each. Most patients don't need IV.
Ketamine vs. SSRIs
Mechanism (glutamate vs. serotonin), time-to-effect (hours vs. weeks), and when ketamine bridges patients during an SSRI adjustment. Not either/or.
How to pick a provider
Three honest filters in order:
- State of residence first. Telehealth ketamine is state-licensed. If you're not in a provider's licensed states, the comparison is moot. Discreet Ketamine serves Florida and New Jersey only.
- Clinical model second. Session-based therapeutic dose has the bulk of the evidence base. Daily microdose is much cheaper but the trial data is thinner — fine if cost is the dominant constraint and you've discussed it with a clinician.
- Continuity third. A network model means a different clinician at intake than follow-up — fine for stable patients, harder when dose adjustments or interaction questions come up. Single-physician continuity costs more per visit but resolves chart questions faster.
Price isn't in this list because every provider lands within a few hundred dollars per month all-in. The differences in clinical model and continuity matter more for outcomes than the price spread.
Common questions
Which provider has the best clinical outcomes?
There aren't public head-to-head outcome studies between at-home providers. The evidence base is for the clinical model — session-based therapeutic dosing of sublingual or oral ketamine — not for any specific brand. Continuity of physician across the treatment arc is the variable most likely to affect outcome day-to-day.
Is daily microdose ketamine clinically equivalent?
No. The therapeutic dosing trials that built ketamine's evidence base used periodic (weekly or twice-weekly) sub-anesthetic doses, not daily microdoses. Joyous's daily-microdose model is plausible but not evidence-equivalent. Patients should discuss it with their prescriber.
Can I switch providers mid-treatment?
Yes. Your medical record travels with you. Most at-home providers will accept a transfer if you send prior visit notes. Adjustment to a new physician's protocol usually takes one session.
Are there providers we're leaving out?
Yes — the at-home market has 10+ smaller providers. The four above represent ~80% of the patient volume in FL and NJ. For broader comparisons see our 2026 cost-comparison guide covering six providers.
Want the Discreet Ketamine version?
Two-minute eligibility check. Florida or New Jersey residents only.