Tech industry burnout has its own clinical signature. Years of high-intensity work in a notoriously demanding industry — combined with the specific cognitive load of complex problem-solving, on-call rotations, layoff anxiety, and the lifestyle pattern of long hours followed by aggressive recovery — produce a recognizable profile: anxiety with somatic symptoms (insomnia, GI issues, jaw tension), recovery time after demanding sprints extending to weeks, intermittent depressive episodes between projects, increasing reliance on stimulants or alcohol to function.
Standard treatment — SSRIs, therapy, exercise — works for many tech workers. For the substantial fraction whose anxiety or depression is treatment-resistant, the next step is where things get harder. Many tech workers I see have cycled through 2-3 SSRIs (Lexapro, Zoloft, Wellbutrin), tried therapy with marginal results, and arrive at ketamine therapy as the "I want a different mechanism" intervention.
The mechanism IS different. SSRIs work on serotonin reuptake over weeks. Ketamine works through glutamate-mediated neuroplasticity within hours. For the 60-75% of treatment-resistant patients who respond, the change is often felt within the first 1-3 sessions: the rumination loops quiet, the catastrophic thinking decompresses, the recovery time after a hard week shortens from days to hours.