Atypical antipsychotic

Latuda (lurasidone) Withdrawal

Latuda (lurasidone) has a moderate discontinuation profile. As with other antipsychotics, the clinically important concerns are return of underlying psychiatric symptoms and rare withdrawal dyskinesia.

By Dr. Ben Soffer, DO — board-certified physician, at-home ketamine therapy in Florida and New Jersey.

Half-life

~18 hours.

Withdrawal timeline

Onset— 2-7 days after stopping

Symptoms emerge gradually.

Peak— Weeks 2-4

Return of underlying symptoms emerges in this window.

Resolution— Variable

Depends on alternative treatment.

Common symptoms

  • Return of underlying condition
  • Anxiety
  • Sleep disturbance

Less common

  • Restlessness

Tapering guidance

  • A typical taper reduces by 20 mg every 2-4 weeks.
  • Coordinate the taper with the prescribing psychiatrist.

Where ketamine therapy fits

Latuda is compatible with at-home ketamine therapy. Continue Latuda as prescribed during ketamine treatment unless the prescribing psychiatrist advises otherwise.

Check ketamine therapy eligibilityMedication safety with ketamine

Frequently asked questions

How long does Latuda withdrawal last?

Return of underlying symptoms emerges over 2-4 weeks. Re-stabilization depends on alternative treatment.

Important: This page is informational and does not constitute medical advice or a recommendation to start, stop, or change any medication. Tapering psychiatric medications should always be coordinated with the prescribing physician. Compounded ketamine for anxiety, depression, PTSD, and chronic pain is not FDA approved.

Browse all medication withdrawal guides.