Half-life
~7 hours. Viloxazine is a newer agent (FDA-approved 2021), so published discontinuation data are limited.
Withdrawal timeline
ADHD symptoms gradually return as the drug clears; an acute withdrawal syndrome is not expected.
Return of inattention and restlessness; some report transient irritability or sleep changes.
Transient effects usually settle within a couple of weeks.
Common symptoms
- Return of ADHD symptoms
- Irritability
- Sleep changes
Less common
- Fatigue
- Headache
- Low mood
Tapering guidance
- A strict taper is usually not required, but a brief step-down after longer use is reasonable - and prudent given the limited data on abrupt cessation.
- Coordinate with the prescribing physician.
Where ketamine therapy fits
Ketamine therapy does not treat viloxazine discontinuation. It can be relevant for co-occurring depression or anxiety alongside ADHD. Because Qelbree has serotonergic activity, mention it to any ketamine-prescribing physician so the full medication picture is considered. See [ketamine for ADHD](/blog/ketamine-for-adhd).
Frequently asked questions
Does Qelbree cause withdrawal?
It is non-controlled and not expected to cause dependence. Data are limited because it is newer, but the main effect of stopping is the return of ADHD symptoms.
Should I taper Qelbree?
A strict taper is usually not required, but a brief step-down after longer use is reasonable. Coordinate with your prescriber.
Can ketamine therapy be combined with Qelbree?
Generally yes, with coordination. Because viloxazine has serotonergic activity, make sure any ketamine prescriber knows you take it.
Important: This page is informational and does not constitute medical advice or a recommendation to start, stop, or change any medication. Tapering psychiatric medications should always be coordinated with the prescribing physician. Compounded ketamine for anxiety, depression, PTSD, and chronic pain is not FDA approved.
Browse all medication withdrawal guides.