Atypical antipsychotic (dopamine partial agonist, related to Abilify)

Rexulti (brexpiprazole) Withdrawal

Rexulti (brexpiprazole) has a mild discontinuation profile similar to Abilify, helped by its very long half-life. Return of underlying symptoms is the most clinically important concern.

By Dr. Ben Soffer, DO — board-certified physician, at-home ketamine therapy in Florida and New Jersey.

Half-life

~91 hours.

Withdrawal timeline

Onset— 1-2 weeks

Gradual onset due to long half-life.

Peak— Weeks 3-6

Return of underlying symptoms emerges over the first month or two.

Resolution— Variable

Depends on alternative treatment.

Common symptoms

  • Return of underlying condition
  • Anxiety
  • Sleep disturbance

Less common

  • Mild GI changes

Tapering guidance

  • A typical taper reduces by 1 mg every 2-4 weeks.
  • Coordinate the taper with the prescribing psychiatrist.

Where ketamine therapy fits

Rexulti is compatible with at-home ketamine therapy. Continue Rexulti as prescribed during ketamine treatment unless the prescribing psychiatrist advises otherwise.

Check ketamine therapy eligibilityMedication safety with ketamine

Frequently asked questions

How long does Rexulti withdrawal last?

The very long half-life means any effects emerge gradually over weeks. Return of underlying symptoms is the main consideration.

Important: This page is informational and does not constitute medical advice or a recommendation to start, stop, or change any medication. Tapering psychiatric medications should always be coordinated with the prescribing physician. Compounded ketamine for anxiety, depression, PTSD, and chronic pain is not FDA approved.

Browse all medication withdrawal guides.