Atypical antipsychotic

Zyprexa (olanzapine) Withdrawal

Zyprexa (olanzapine) has a moderate discontinuation profile. Rebound insomnia and anxiety are common in the first 1-2 weeks. Return of underlying psychiatric symptoms is the more clinically important long-term concern. Withdrawal dyskinesia, while uncommon, is recognized.

By Dr. Ben Soffer, DO — board-certified physician, at-home ketamine therapy in Florida and New Jersey.

Half-life

~21-54 hours.

Withdrawal timeline

Onset— 2-5 days after stopping

Symptoms emerge within a week.

Peak— Week 1-2

Rebound insomnia and anxiety peak in the first 2 weeks.

Resolution— 2-4 weeks acute; relapse risk extends longer

Acute symptoms resolve over weeks; underlying-condition relapse is separate.

Common symptoms

  • Rebound insomnia
  • Anxiety
  • Nausea
  • Restlessness
  • Vivid dreams
  • Return of underlying condition

Less common

  • Headache
  • Withdrawal dyskinesia (rare)

Tapering guidance

  • A typical taper reduces by 2.5-5 mg every 1-2 weeks.
  • For psychotic disorders, coordinate the taper carefully with the prescribing psychiatrist; relapse risk is substantial.
  • Coordinate any taper with the prescribing physician.

Where ketamine therapy fits

Zyprexa is compatible with at-home ketamine therapy. Continue Zyprexa as prescribed during ketamine treatment unless the prescribing psychiatrist advises otherwise.

Check ketamine therapy eligibilityMedication safety with ketamine

Frequently asked questions

How long does Zyprexa withdrawal last?

Acute rebound symptoms typically peak in the first 2 weeks and resolve over 2-4 weeks. Relapse risk for the underlying condition extends longer.

Is Zyprexa compatible with ketamine therapy?

Yes. Continue as prescribed unless your physician advises otherwise.

Important: This page is informational and does not constitute medical advice or a recommendation to start, stop, or change any medication. Tapering psychiatric medications should always be coordinated with the prescribing physician. Compounded ketamine for anxiety, depression, PTSD, and chronic pain is not FDA approved.

Browse all medication withdrawal guides.